Los controles no relacionados (n = 240) se obtuvieron al azar de la base nacional de datos de donantes cadavéricos. Ninguno de los pacientes tenía el alelo HLA-B*51 determinado al inicio del estudio. Incluimos en forma consecutiva 34 pacientes argentinos con diagnóstico definitivo de EB entre los meses de octubre de 2016 y marzo de 2017.

Our finding is consistent with previous studies indicating that the HLA-B*51 allele is an important susceptibility gene in BD regardless the geographical region and ethnicity.Įvaluar la asociación entre el alelo HLA-B*51 y la enfermedad de Behçet (EB) en pacientes argentinos. The HLA-B*51 allele is strongly associated with BD in Argentinean patients. The association between BD and HLA-B*51 allele was greater than that of control group (OR = 3.75 p = 0.0012). Thirty-four (14.2%) of 240 controls were positive for the HLA-B*51 allele.

Thirteen (38.2%) of 34 cases were HLA-B*51 allele positive 11 were heterozygous and 2 homozygous for the allele. Nineteen (55.8%) were male, and the mean age at diagnosis was 35 years old twenty (58.8%) were Mestizos, 8 (23.5%) were Caucasian, and 6 (17.6%) were Amerindians. Demographic and clinical features of the patients were recorded by attending physicians through a questionnaire. Unrelated controls ( n = 240) were randomly obtained from the national cadaveric donor database. None of the patients had the HLA-B*51 allele determined at study entry. We enrolled 34 consecutive Argentinean patients with definitive diagnosis of BD between October 2016 and March 2017.

To assess the association between the HLA-B*51 allele and Behçet Disease (BD) in Argentinean patients.

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